AKT1 and acute kidney injury: Maadawy, Walaa Het al. [96] found that 6-Paradol alleviates diclofenac induced AKI byregulating autophagy enhancement mediated by AMP-activated protein kinases/AKT kinase/mammalian target of rapamycin (AMPK/AKT/mTOR) and the NLRP3inflammasome pathway.