Univariate linear regression analysis was established in all CHDpatients with β values as the dependent variable with age, gender, BMI,history of smoking and drinking, hypertension, atrial fibrillation, heartfailure, LDL-C, HDL-C, triglyceride, total cholesterol, Hb, glucose, RBP4, CRP,CK-MB, cardiac troponin T, NT-proBNP, and T2DM as independent variables,respectively. The gene discussed is NPPB; the disease is type 2 diabetes mellitus.