In the Risk for CardiovascularEvents Study of 1005 male and female, median follow-up of 3 years, β2M levels(Q4: ≥2.59 VS Q1: ≤1.49 mg/L) was positively associated with anincreased risk of stroke, adjusted HR (95% CI) was 1.62 (1.16–2.67) [32]. This evidence concerns the gene B2M and Stroke.