Previous studies have also indicated that the β2M waspositively associated with all-cause mortality in participants with chronickidney disease , HR and 95% CI: 2.52 (1.89, 3.36) [9], chronic obstructive lungdisease, HR and 95% CI: 1.09 (1.05, 1.14) [10], diabetes, HR and 95% CI: 7.35(1.01, 53.38) [33], cancer, HR and 95% CI: 1.25 (1.06–1.47) [34], hemodialysismortality, HR and 95% CI: 1.09 (1.05–1.14) [35], and CVD, RR and 95% CI: 2.29(1.51–3.49) [36]. The gene discussed is B2M; the disease is cancer.