Recently, a thoroughexamination of skeletal muscle biopsies in HF patients and age-matched controlsperformed by Bekfani et al. [11] has pointed that HF patients with lowermuscular endurance presented with elevated expression of the inflammatorybiomarker GDF-15 and atrophy-related factors [Atrogin1, F-box only protein 32(FBXO-32), and Myostatin-2 (MSTN-2)], which further supports the detrimentaleffect of inflammation towards muscle wasting. Here, GDF15 is linked to hydrops fetalis.