CD68 and Cowden syndrome 1: A combination of some novel surrogate histological findings, such asmicrogranulomas, increased number of dendritic cells, the accumulation ofpro-inflammatory M1 (CD68+CD163-) macrophages and decreased number ofanti-inflammatory M2 (CD68+CD163+) macrophages, lymphangiogenesis(increased lymphatic vessel count), confluent fibrosis and fatty infiltration,the detection of monoclonal antibody against Propionibacterium acnes byimmunohistochemistry may be useful in the histological diagnosis of CS in theabsence of typical non-caseating granulomas [72, 73, 74, 75].