SKI and Marfan syndrome: Although there is a very clear gene-phenotypeassociation, other genes such as FBN2, transforming growthfactor β receptor 1 (TGFBR1), transforming growth factorβ receptor 2 (TGFBR2), latent transforming growth factorβ -binding protein 1 (LTBP-1), latent transforming growth factorβ -binding protein 2 (LTBP-2), latent transforming growth factorβ -binding protein 3 (LTBP-3) and ski proto-oncogene (SKI) have been described in MFS cases [21].