MYH6 and 22q11.2 deletion syndrome: While the genetic cause of thiscongenital disorder is still unknown, some studies indicate that recessivevariants in MYH6 could account for at least 11% of Shone’s cases [71].Velocardiofacial syndrome (VCFS), the most common microdeletion syndrome inhumans, manifests a wide variety of presentations and phenotypes includingcongenital heart disease resulting in BAV [64, 72].