Since thefirst GWAS performed by Dina et al. [11], several genes have beenassociated with sporadic MVP cases: LIM and cysteine-rich domains protein1 (LMCD1), tensin-1 (TNS1), glioma-associated oncogene homolog-similar 1 (GLIS1), synaptotagmin 2 (SYT2), methioninesulfoxide reductase A (MSRA), F-box protein 46 (FBXO46),spectrin β chain, non-erythrocytic 1 (SPTBN1), latenttransforming growth factor β-binding protein 2 (LTBP2), transforminggrowth factor β 2 (TGFB2), neuromedin B NMB, andα-protein kinase 3 (ALPK3)  [12, 13]. Here, FBXO46 is linked to familial mitral valve prolapse.