These findings indicate that cathepsinproteins hold great potential as a therapeutic target for treating EC senescence.Yu et al. [41] revealed that elevated levels of cathepsin proteins inplasma were closely linked to coronary artery disease, providing evidence thatcirculating cathepsin proteins could be a promising biomarker for this condition.Furthermore, research on human atherosclerotic lesions and narrowed aortic valveshas shown that, apart from cathepsin K and S, there is a notable increase in bothmRNA and protein expression levels of cathepsin V [42]. The gene discussed is CTSS; the disease is coronary artery disorder.