In fact, research hasillustrated that IFN-γ triggers hypertension by heighteningangiotensinogen expression in rat proximal renal tubule cells in aJAK2/STAT3-dependent manner [87], thereby leading to an augmented blood volume.However, according to Ishimitsu et al. [88], IFN-γ amelioratedthe development of hypertension and vascular and renal injuries in Dahlsalt-sensitive rats. Here, STAT3 is linked to hypertensive disorder.