IL1B and Hypertension: In another study focused on salt-sensitivehypertension, it was discovered that IL-1β released from renal tubularepithelial cells in diabetic mice can promote hypertension by polarizingmacrophages into the M1 subtype, resulting in the excessive release of IL-6.However, this effect can be attenuated by inhibiting the synthesis ofIL-1β in immune cells or knocking out the IL-1 R1 receptor [83].Therefore, targeting IL-1β may offer a promising treatment strategy forhypertension.