Alcohol use, lactation or pregnancy, athlete and menopausal, inflammatory conditions (e.g., hypertension and infection), family history of hyperlipidemia, CVD, renal, lung, or liver disease, biliary disease, cancer, liver transplantation, autoimmune disease, injuries and burns during the research, surgery in the last three months, taking medications (e.g., insulin sensitivity enhancers, antihypertensives, statins, hepatotoxic drugs, estrogens, contraceptive pills, or antioxidants) in the last two months. This evidence concerns the gene INS and autoimmune disease.