Are the atherogenic biomolecules such as serum/plasma/tissue levels of ROS,NADPH-oxidase, NF-κB, CAM, cytokines, MCP-1, GM-CSF, PAF, LTB4,activated complements, IGF-1, and TGF-1 elevated in hypercholesterolemia? Here, CSF2 is linked to familial hypercholesterolemia.