TNNI3 and cardiomyopathy, familial restrictive, 1: The geneticmutations associated with the occurrence and progression of RCM involve sarcomereproteins, such as troponin I (TNNI3), troponin T (TNNT2),β-myosin heavy chain (MYH7) and α-actin(ACTC1) [13, 14, 15].