The KEGG pathway enrichment analysis suggestedthat the TNF signaling pathway, hypoxia inducible factor-1 (HIF-1) signaling pathway, FoxO signaling pathway,PI3K-Akt signaling pathway, and other signaling pathways may associated with theoccurrence and development of CHD and AS (Fig. 7A). The gene discussed is TNF; the disease is coronary artery disorder.