Moreover, knockdownof BMP4 in adipocytes leads to increased production of pro-inflammatorycytokines, which trigger endothelial cell inflammation and promote AS [15].Mazzotta et al. [13] compared the differences in gene expression betweenPVAT of the aorta, which is atherosclerosis-prone, and that of the internalmammary artery (IMA), which is atherosclerosis-resistant, and the result foundthat these differential genes are enriched in signaling pathways related to AS[13]. This evidence concerns the gene BMP4 and atherosclerosis.