This trend aligns with previous preclinical studies associating high-powerstandard-duration ablations (i.e., 50 W for 30 seconds) to a higher risk of microembolic events compared to standard RF ablation power settings [39].In a substudy of the AXAFA-AFNET 5 Trial (Anticoagulation Using the Direct Factor Xa Inhibitor Apixaban During Atrial Fibrillation Catheter Ablation: Comparison to Vitamin K Antagonist Therapy), which included 335 patients undergoing brain magnetic resonance imaging (MRI) after AF ablation, acute brain lesions were detected in 25% of the patients [40]. This evidence concerns the gene F10 and atrial fibrillation.