In dilated cardiomyopathy, the aspartate-to-alanine substitution atposition 94 in the regulatory light chain of myosin (RLC) encoded by the myosin regulatory light chain 2 (MYL2) gene results in anincreased number of SRX heads and a subsequent reduction in myocardial contractility[45]. This evidence concerns the gene MYL2 and dilated cardiomyopathy.