MFN1 and cardiac hypertrophy: Both Mfn1/Mfn2 and DRP1 conditional knockout lead toprogressive left ventricular enlargement and decreased ejection performance.However, the conditional knockout of Drp1 lead to dilated heart disease, whereasthe conditional knockout of Mfn1/Mfn2 lead to cardiac hypertrophy [116, 118].Drp-1, together with Fis-1, functions to ensure equal division of the number ofmitochondria during cell division and mediate the clearance of damagedmitochondria by mitochondrial autophagy.