AGT and cardiac hypertrophy: The high expression of miR-17-5p is involved in theoccurrence of ventricular hypertrophy by targeting Mfn2 and inhibiting mitophagy.Further studies showed that in Ang II-induced NRVM, overexpression of Mfn2 couldinhibit the Phosphoinositide 3-kinase/Murine thymoma viral oncogenehomolog/mechanistic target of rapamycin signaling pathway and enhancecardiomyocyte mitophagy, thereby alleviating the pathological process of cardiachypertrophy [114].