Pathophysiological changes stemming from HF havebeen closely correlated with the development of ventricular arrhythmias [54].Mouse heart models with specific knockdowns of Mfn1 and Mfn2 genes presentedexcessive mitochondrial fragmentation within the myocardium, coupled withaberrant respiratory chain function, culminating in lethal HF [55]. This evidence concerns the gene MFN1 and hydrops fetalis.