During theinitial activation phase of sepsis, necrotic tissue and microorganisms producedamage-associated molecular patterns (DAMPs) and pathogen-associated molecularpatterns (PAMPs), which then activate pattern recognition receptors (PRRs, suchas TLRs) on the cytomembrane, triggering a series of intracellular signal eventsand leading to a cascade of release of inflammatory factors (such asNF-κB, IL-6, TNF-α, HMGB1, and NLRP3). This evidence concerns the gene IL6 and Sepsis.