Mechanistically, MALAT1/miR-146/NF-κB,LUADT1/miR-195/PIM-1, and HULC/miR-204-5p/TRPM7 are critical signaling pathwaysthat regulate LPS-induced endothelial injury and associated vascular paralysis.These findings reveal novel targets in the lncRNA-miRNA-mRNA axis associated withendothelial dysfunction and provide potential biomarkers for sepsis-relatedvascular diseases. Here, MALAT1 is linked to Sepsis.