It is worth noting that MALAT1, GAS5 and NF-κB are highly expressed andXIAP is expressed at low levels both in vivo and in vitro inSCVDs, which may be the key molecules for sepsis-induced cardiovascular toxicity.Among them, miR-146, miR-150, miR-150-5p, and miR-26a are common vector spongesbetween MALAT1 and NF-κB, and negatively regulate cardiotoxicity [36, 38, 57, 58]. The gene discussed is NFKB1; the disease is Sepsis.