Moreover, treatment withthe main flaxseed oil polyphenol SDG decreased levels of TAGs, total cholesterol(TC) and LDL-C and increased vessel density and heme oxygenase-1 (HO-1), and up-regulatedexpression of vascular endothelial growth factor (VEGF) and phosphorylated endothelial nitricoxide synthase (p-eNOS) in male SP rats with diet-induced hypercholesterolemia [85]. Here, HMOX1 is linked to familial hypercholesterolemia.