It has been reported that (R)-4-Acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one (CCR2 RA [R]), a CCR2 antagonist, at 14 and 28 days after nerve injury significantly reduced bilateral nociceptive behavior (pain sensitivity). Here, CCR2 is linked to injury.