Although the molecular functions of LRBA protein have been described in the recycling of CTLA-4 in T regulatory cells (2), a significant proportion of patients with LRBA deficiency present defects in the number of memory B cells, low serum antibodies, and autoimmunity such as thrombocytopenia and hemolytic anemia (1), suggesting an additional mechanism of LRBA in the correct function of B cells. This evidence concerns the gene LRBA and Autoimmunity.