CD4 and neoplasm: In contrast, in the two-tumor B78 model shown in Figure 2, where local RT and i.t. IL-12 to the right flank combined with systemic srIL- 2 and anti-CTLA-4 enabled eradication of both tumors in many mice (Figure 2C), a similar depletion of CD4 and CD8 T cells significantly reduced the antitumor effect against the secondary tumor in the left flank (Figures 3E, F).