In contrast, RT and IL-12 applied to the primary tumors in combination with systemic srIL-2 and anti-CTLA-4 in a two-tumor model, induced eradication of 5 out of 5 of the primary tumors (mean volume 197 mm3), and 3 out of 5 of the distant tumors (mean volume 261mm3) (Figure 7B). Here, CTLA4 is linked to neoplasm.