Compared with those in normal human colonic cells (NCM460 cells), the expression of ACAA2 was significantly higher in HCT116 and CACO2 cells, while the expression of ACSF2, DDR2 and SLC22A5 was significantly increased in the CRC cells (Figures 5A, B). This evidence concerns the gene SLC22A5 and colorectal carcinoma.