After removing confounder-associated SNPs (rs10774624) (Supplementary Table S20), our results indicated that IL-17A (OR, 0.66; 95%CI, 0.51–0.87; P = 2.63E-03; PFDR = 1.32E-02) and IL-27 (OR, 0.75; 95%CI, 0.59–0.95; P = 1.70E-02; PFDR = 8.50E-02) were significantly associated with lower risks of obstructive hydrocephalus and normal-pressure hydrocephalus, respectively (Figure 7 and Supplementary Table S21). The gene discussed is IL27; the disease is normal pressure hydrocephalus.