Another retrospective analysis evaluated 131 SNSCCs with immunohistochemistry for PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection to explore antitumor efficacies of immune checkpoint inhibitors (ICIs) and the usefulness of potential predictive markers in SNSCC (17). This evidence concerns the gene EGFR and neoplasm.