Besides, tumor endothelial cells are activated by cytokines like TNF-α and IL-1 secreted by TRMs, causing upregulated expressions of adhesion molecules (such as ICAM-1, VE-cadherin and junctional adhesion molecules) and chemokines (such as CCL5, CXCL8, and CXCL12), leading to increased adhesiveness of activated lymphocytes in the TME (61–63). This evidence concerns the gene CXCL12 and neoplasm.