(3) Adhesion: activated integrins on lymphocytes bind to adhesion molecules like intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), glycosylation-dependent cell adhesion molecule-1 (GlyCAM-1), and mucosal addressin cell-adhesion molecule-1 (MadCAM-1) on tumor endothelial cells (18), mediating lymphocyte residence and firm adhesion. This evidence concerns the gene MADCAM1 and neoplasm.