Recent studies indicate that inhibiting neprilysincan impede the activation and proliferation of cardiac fibroblasts, which isattributed to the restoration of PKG signaling within fibroblasts [51].Furthermore, ANP has been shown to stimulate mitochondrial autophagy, enhancemitochondrial function, and lower intracellular oxidative stress levels [52].Patients with hypertension exhibit elevated levels of NPs [47]. This evidence concerns the gene NPPA and hypertensive disorder.