It has been demonstrated that NPs are closelyassociated with the development of LVH and HF resulting from hypertension [23].Upon binding of ANP and BNP to natriuretic peptide receptor (NPR), the activationof guanylate cyclase ensues, leading to increased levels of cyclic guanosinemonophosphate (cGMP) [47]. Here, NPPA is linked to Hypertension.