To analyze sST2, GDF-15, H-FABP, IGF-BP2 and suPAR as potential biomarkers forprediction of an sPAP ≥40 mmHg in patients with severe AS before TAVR,AUROC-curves regarding plasma level concentration of examined biomarkers werefigured out. The gene discussed is IGFBP2; the disease is aortic valve stenosis.