The BNP cut-off value for the presence of PH was 2248 pg/mL, which isrelevantly higher than the cut-off levels (58–190 pg/mL) compiled by Parikhet al. [35] for the prediction of symptoms in the setting of severe AS.Here, it is clear how a consequent right heart strain arising from PH influencesthe secretion of BNP. This evidence concerns the gene NPPB and aortic valve stenosis.