CSRP3 and atrial fibrillation: The results demonstrated that CSRP3(Area Under Curve, AUC 0.843), MCOLN3 (AUC 0.771),SLC25A5 (AUC 0.795), and FIBP (AUC 0.735) had a general abilityto discriminate between AF with VHD and SR with VHD (Fig. 9A).Multiple biomarkers were combined as a sensitive screeningindex for AF-VHD in order to improve the diagnosis sensitivity.