Previous studies have shown that PKM2influences the initiation and progression of atherosclerosis by regulatingmetabolic reprogramming, immune activation, and tissue inflammation [32, 33].However, there is limited evidence on the role of PKM2 in vascular calcification.Our study fills the gaps and shows that the expression of serum PKM2 issignificantly upregulated in CAC patients. This evidence concerns the gene PKM and atherosclerosis.