Several studiesillustrated that L-T3 therapy increases the expression of hypoxia-induciblefactor-1α (HIF-1α) and mitochondrial transcription factor A(mt-TFA), which have an important role in maintaining cell survival duringmyocardial ischemia, attenuating left ventricular remodeling and preservingpost-MI cardiac performance [63, 64, 65]. This evidence concerns the gene HIF1A and myocardial infarction.