Currently, both in vivo and in vitromodels indicated that the lncRNA maternally expressed 3 (MEG3) was upregulatedduring ischemic AKI, targeting miR-129-5p, and elevating the expression ofhigh-mobility group box-1 (HMGB1), a protein intensively released by necrotictubular epithelial cells in the AKI, conducting inflammation and apoptosis aswell [62]. This evidence concerns the gene MEG3 and acute kidney injury.