Unlike the previous SIRT3 study, Gu et al. [103] reported that thepolycomb protein PH19 reduced H3K36m3 and increased H3K27m3 of gene promoter ofSIRT2 in cardiomyocytes and heart tissue treated with AngII, providing anexponential expression of ANF and BNP, and consequently cardiac hypertrophy. This evidence concerns the gene NPPA and cardiac hypertrophy.