ATP2A2 and hydrops fetalis: Modifications inH3 and H4 in mice hearts were also observed 8 weeks after inducing HF by TAC.ChIP indicated that the H3K4me2 histone marking in the Atp2a2 gene promoter, theSERCA2 gene, was significantly reduced in the TAC group, whereas there was anincrease in the Myh7 gene promotor, the pβ-MHC corresponding gene.Additionally, ChIP analysis of the Atp2a2 gene promoter presented an elevatedH3K36me2 level, resulting in recruiting DNMT1 and DNMT3b and the methyl CpGbinding protein 2 (MeCp2).