HF biomarkers can be classified into severalcategories: biomarkers associated with myocardial and vascular stretching, suchas BNP, NT-proBNP, troponins; biomarkers that reflect an alteration in theneurohormonal pathways and RAAS; biomarkers seen in inflammation and theoxidative process; and finally, biomarkers associated with myocardial andvascular fibrosis, such as suppression of tumorigenicity 2 (ST2) and galactin 3[129]. The gene discussed is NPPB; the disease is hydrops fetalis.