TNC also contributes to fibrosis [24], and aggravatesfibrotic remodeling in cardiac tissue after myocardial infarction [51].Fibronectin-TNC aggregates are normally not present in the basement membranes butupon formation cause basement membrane thickening of retinal vessels in diabeticretinopathy [7]. The gene discussed is FN1; the disease is myocardial infarction.