TNC and diabetes mellitus: Diabetes was induced by streptozotocin (STZ) injections (n = 7–11 animals ineach group) in Tenascin C KO (TNC KO) mice and their Wild type (A/J) littermates.After 16–18 weeks the heart was removed and the whole subsurface network of theleft coronary artery was prepared (down to branches of 40 μm outerdiameter), in situ pressure-perfused and studied using video-microscopy.Outer and inner diameters, wall thicknesses and bifurcation angles were measuredon whole network pictures reconstructed into collages at 1.7 μmpixel resolutions.