In addition, statistically significant trends of increase in COVID-19severity, frequencies of diabetes mellitus and obesity, CRP, ferritin, WBC,hemoglobin, platelets, IL-6 and procalcitonin, as well as statisticallysignificant trends of decrease in frequencies of age, comorbidity burden,frequencies of arterial hypertension and hyperlipoproteinemia were observed overrising quartiles of RHR (p < 0.05 for all analyses). The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.