In univariate analysis, higher uNAG level was associated with significantlyincreased risks for all-cause mortality, HF rehospitalization, and the compositeof all-cause death or HF rehospitalization (Supplementary Table 1).Multivariable Cox analysis adjusted for sex, age, CAD, hypertension, diabetes,CKD, NT-proBNP, LVEF, MR grade, intravenous use of diuretics, and urinarymicroalbumin was performed. The gene discussed is NPPB; the disease is Hypertension.