Angiotensin-inducedexpression of profibrotic proteins in neonatal CFs was significantly decreased bypiperlongumine treatment, reducing the expression of Krüppel-like factor 4(KLF4), and its recruitment to the promoter regions of the pro-fibrotic cytokinesTGF-β and connective tissue growth factor (CTGF). The gene discussed is CCN2; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.