It also attenuates nitric oxide-mediated vasodilationand participates in the vascular pathology of MetS, atherosclerosis and CHD [67].IL-6 makes for insulin resistance, enhances the synthesis of acute phase proteinssuch as CRP and fibrinogen in the liver, promotes the expression of endothelialcell adhesion molecules, and activates the renin-angiotensin system. This evidence concerns the gene IL6 and atherosclerosis.