PPARGC1A and Hypertension: Physical exercise activates theperoxisome proliferator-activated receptor-γ coactivator 1 alpha(PGC-1α) pathway, which reduces pathological myocardial remodeling,improves hypertension, reduces cardiac apoptosis and collagen accumulation, andbeneficially modulates several genes related to mitochondrial biogenesis [70].Activation of the PGC-1α pathway also helps reduce myocardial andsystemic inflammation by inhibiting infiltration of macrophages, TNF-α,and inducible nitric oxide synthase, including inhibition of chemokines andcytokines in the bloodstream [71].