FH and coronary artery disorder: Moreover, geneticconfirmation of FH is extremely helpful in identifying subjects with the highestrisk for ASCVD, since the presence of a “classic” FH mutation in subjects withLDL-C levels >190 mg/dL (>4.9 mmol/L) results in a 3.7-fold increased coronary heart disease (CHD)risk, compared to subjects with equally elevated LDL-C but not carrying a geneticvariant.