However, it has been suggested in atherosclerosis that ANGPT1/Tie2 playanti-angiogenic, anti-inflammatory, and anti-atherogenic roles [101, 102].Several studies have revealed that the functions of ANGPT1 and ANGPT2 inatherosclerosis are complex and paradoxical [103, 104, 105, 106]. Here, ANGPT1 is linked to atherosclerosis.