Similarly, anotherstudy showed that silencing of the HIF-1α gene alleviatedaneurysm enlargement, angiogenesis, and expression of pro-angiogenic andpro-inflammatory factors [67], such as VEGF, Flt-1, MMP-2, and MMP-9, in an AngII-infused AAA model. This evidence concerns the gene HIF1A and triple-A syndrome.