APOE and Alzheimer disease: According to Yu’s report, recombinant ANGPT2 administrationsignificantly inhibited angiogenesis, monocyte/macrophage infiltration, aorticdilatation, and rupture in an Ang II-induced ApoE-⁣/- mouse AA model [99].Similarly, Chen et al. [100] analyzed the DNA methylation patterns oftype A-AD and controls to explore epigenetic changes during ADprogression.