HIF1A and triple-A syndrome: Wang et al. [69] reported that cyclooxygenase-2(COX-2) upregulated HIF-1α/VEGF signaling, leading to angiogenesis andAAA formation in a CaCl2-induced mouse model; however, this biologicalprocess could be inhibited by quercetin, a flavonoid extracted naturally and hasbeen validated to inhibit AAA progression by limiting oxidative stress andinflammatory response.