There were significant differences in 12 variables between SAE group and non-SAEgroup, including BMI, NT-proBNP, LDH, cTnI, Urea, NEUT, heart failure, pulmonaryartery hypertension, severity of congenital heart disease, procedure type, ASAscore, and access location (p < 0.05) (Table 2). The gene discussed is NPPB; the disease is heart failure.