Moreover,skin-specific NLRP3 suppression can inhibit the proliferation and chemotaxis ofkeratinocytes through the downregulation of IL-1β, IL-23, IL-17A, C-X-Cmotif chemokine ligand 1 (CXCL1), as well as the improvement of Treg/Th17 ratio,thus ameliorating the skin lesions induced by psoriasis [19]. The gene discussed is CXCL1; the disease is psoriasis.