Besides, we alsoidentified sevreal serum characteristics of immune disorder in atherosclerosisand furtherly linked NLRP3 with them: (i) In patients with atherosclerosis, theTh17 cell frequency and Treg-regulated anti-inflammatory cytokines was enhanced,whereas the Treg cell frequency, Th17-related inflammatory cytokines, and theTreg/Th17 ratio dropped. Here, NLRP3 is linked to immune system disorder.