This study finds that serum NLRP3 level may reflect the Treg/Th17 ratio inindividuals with atherosclerosis, however, some limitations remain existing.Significantly, the current findings of this study reveal a negative correlationbetween serum NLRP3 level and the ratio of Treg/Th17, which can be applied to therisk assessment of atherosclerosis. The gene discussed is NLRP3; the disease is atherosclerosis.