Interestingly, the inhibition of lipoproteinreceptor-related protein 6 (LRP6) via miRNA-LRP6 resulted in increasedproliferation of CM along with stem cell differentiation towards CM [72].Additionally, the deficiency of LRP6 improved heart function with a concomitantreduction in infarct size as evident from MI-mouse model [72]. This evidence concerns the gene LRP6 and myocardial infarction.