GCG and diabetes mellitus: While CRF is a long-established independent predictor of CVD and overallmortality among subjects with diabetes and promotion of PA and higher CRF confercardiometabolic benefits in proportion to the level of fitness (independent ofbody mass index (BMI)), the recent introduction of sodium glucose transporter-2inhibitors (SGLT2i) and incretin modifiers such as glucagon like peptide-1agonists (GLP-1a) in DM2 treatment has already impacted diabetes managementsignificantly.