NLRP3 and colitis: Recent studies revealthat PAP-1 (a Kv1.3 channel-specific blocker) downregulates Kv1.3 expression inmacrophages in mice with colitis and inhibits macrophage activation [107].Moreover, PAP-1 effectively inhibits the expression of NLRP3,ASC, caspase-1p20 and IL-1β.