The latter is also mediated by glutathione-S-transferase (GST), particularly GST π (GSTP1), which is highly expressed in malignant tumors and maintains stemness by detoxifying reactive oxygen species (ROS) and DNA-damaging compounds, conferring apoptosis resistance (Cui et al., 2020; Niitsu et al., 2022). This evidence concerns the gene GSTP1 and cancer.