The DC(I + II) NPs were more effective than DC(I) NPs in increasing ROS (9.1 and 4.7 folds) and lipid peroxidation (3.5 and 2.5 folds), as well as depleting GSH (9.3 and 2.51 folds) and ALDH2 activity (81.82% and 56.07%) in tumor tissues of the liver and lung, respectively. This evidence concerns the gene ALDH2 and neoplasm.