ROC analysis for diagnosis of PAD showed that the area under the curve was 0.771(95% CI, 0.672–0.852; p< 0.001) for galectin-3 and 0.786 (95% CI,0.688–0.864; p< 0.001) for CRP (Fig. 1a,b). This evidence concerns the gene LGALS3 and peripheral arterial disease.