Furthermore, research has consistentlyindicated that elevated galectin-3 levels are linked to adverse cardiovascularoutcomes in both chronic kidney disease patients and those on dialysis [31, 34].Zhang et al. [35] conducted a study indicating that combining pulse-wavevelocity and galectin-3 can predict cardiovascular complications in HD patients.Our study aligns with prior research by demonstrating that galectin-3 and CRP areassociated with ABI values and serve as independent risk markers for PAD among HDpatients, as shown through multivariable logistic regression analysis. The gene discussed is CRP; the disease is chronic kidney disease.