A study has foundthat in the pathogenesis of obese-related AF, gut microbiota dysregulation andincreased lipopolysaccharide (LPS) could affect atrial pathologic remodelingthrough the activation of ferroptosis and the NF-κB/NLRP3 inflammasomesignaling pathway [60]. The gene discussed is NFKB1; the disease is atrial fibrillation.