A strongcorrelation exists between inflammatory cytokines and AF, underscoring theimportance of inflammatory signaling pathways, such as NOD-like receptor thermal protien domain associated protein 3 (NLRP3) inflammasome,Nuclear Factor kappa B (NF-κB) signaling, and Tumor necrosis factor-α (TNF-α) signaling in AF development.Ferroptosis, a non-apoptotic regulated mode of cell death, has been widelystudied in relation to cardiovascular diseases including heart failure,myocardial infarction, cardiomyopathy, and reperfusion injury. This evidence concerns the gene NLRP3 and atrial fibrillation.