A study has foundthat a high-fat diet may induce AF through an intestinal flora imbalance leadingto lipopolysaccharide production, which could result in ferroptosis of atrialcells and the enhancement of the TLR4/NF-κB/NLRP3 inflammasome signalingpathway [60]. The gene discussed is TLR4; the disease is atrial fibrillation.