This resulted in sustained high expression ofrenin in the liver, leading to increased plasma renin activity and Ang II levels.Within 4 weeks, the mice exhibited increased systolic blood pressure, increasedthickness of the interventricular septum and left ventricle posterior wall,myocardial fibrosis, increased infiltration of macrophages, and increasedexpression of TNF-α and TGF-β1. This evidence concerns the gene TGFB1 and Myocardial fibrosis.