Results from the CODAM (Cohort on Diabetes and Atherosclerosis Maastricht) study [7]suggest that individuals who smoke heavily and have elevated C3 levels are more likely to develop coronary heart disease.King R and colleagues discovered that by blocking the connection betweencomplement C3 and fibrinogen, there may be a decrease in cardiovascular eventsfor diabetic patients [8]. This evidence concerns the gene C3 and diabetes mellitus.