After adjusting the confounders including gender, smoking history,diabetes, hypertension, TG, TC, HDL-C, LDL-C and ApoB, the CC genotypeof rs7257062 was identified to be an independent risk factor for CAD (OR= 1.581, 95% CI: 1.094–2.284, p = 0.015). This evidence concerns the gene APOB and Hypertension.