The PIONEER-HF (Comparison of Sacubitril/valsartan versus Enalapril onEffect on N-terminal pro-B-type natriuretic peptide (NT-proBNP) in Patients Stabilized from an Acute HF Episode) trialdemonstrated that the addition of Sacubitril/valsartan in patients hospitalisedwith acute HF led to significantly greater NT-proBNP reductions compared withenalapril therapy (ratio of change 0.71; 95% CI 0.63–0.81; p <0.001) [28]. The gene discussed is NPPB; the disease is hydrops fetalis.