Another case–control studyreported an association between FADS1/rs174556,FADS2/rs174617, and obesity, by demonstrating that plasmalevels of omega-6 PUFAs and AA were higher in overweight and obese patients;however, the difference in ω-3 PUFA levels was not significant. Here, FADS2 is linked to obesity due to melanocortin 4 receptor deficiency.