Thestudy concluded that mutations in the FADS1/FADS2 locus couldcause metabolic disorders and increase the risk of cardiovascular disease [59].Genome-wide association studies (GWAS) in European and Asian populations haveshown that FADS1/rs174546 is associated with reducedΔ5 fatty acid desaturase activity, obesity, and the risk of insulinresistance [60]. Here, FADS1 is linked to obesity due to melanocortin 4 receptor deficiency.