The effect of FADS gene cluster variants on ASCVD is mainly due to regulatingthe metabolism of PUFAs in the body, by altering fatty acid desaturase activity.In addition, exogenous supplementation of PUFAs can reverse the adverse effectsof certain FADS gene cluster variants, suggesting that certain FADSgene-deficient disorders can be treated by increasing the intake of PUFAs thatcan prevent or alter the course of cardiovascular diseases. This evidence concerns the gene SCD and cardiovascular disorder.