FADS1 and aortic stenosis: Forexample, a Mendelian randomization study of European and American populationsshowed that plasma ALA and LA levels were higher in the FADS1/rs174547 sub-allele population and that this populationwas less likely to have CAD, stroke, and aortic stenosis, thereby suggesting thatthe FADS1 SNP drives the association between plasma levels of PUFAs andASCVD [66].