These factors lead to increased levels of plasma inflammatory cytokines in DM, including C-reactive protein (CRP) (71), interleukin-6 (IL-6), interleukin 1β (IL-1β), interleukin 8 (IL-8) (72), tumor necrosis factor-α (TNF-α), and so on (73). This evidence concerns the gene IL6 and diabetes mellitus.