In addition,astragaloside IV can regulate the release of peroxisome proliferator-activatedreceptor-γ coactivator-1α (PGC-1α) and nuclearrespiratory factor-1 (Nrf-1) to rescue the abnormal myocardial mitochondrialenergy metabolism, thus decreasing the myocardial damage in DCM [130]. Here, NRF1 is linked to familial dilated cardiomyopathy.