This has made them a highly visible and reliable candidate in thefield of diabetes drug discovery, which is receiving increasing attention [157].Some alkaloids can intervene in the insulin signal transduction pathway, reversemolecular defects resulting in insulin resistance and glucose intolerance [158].Along with the in-depth research and application of alkaloids in the field ofdiabetes, the value of alkaloids in the treatment of DCM has become increasinglyapparent. The gene discussed is INS; the disease is diabetes mellitus.