TGFB1 and Myocardial fibrosis: Genistein can attenuate myocardial fibrosis in T1DMrats, where the underlying mechanisms may be associated to a reduction of serumcreatine kinase MB isozyme (CK-MB), lactate dehydrogenase (LDH) leakage, andsuppression of the TGFβ1/Smad3 signaling pathway [62].