Throughthe Nrf-2 signaling pathway, 19 types of natural products considered herepresented the myocardial protective effects of anti-oxidative stress,anti-inflammation, anti-apoptosis, and myocardial fibrosis inhibition.TGF-β plays an important role in the pathogenesis of cardiac remodelingand myocardial fibrosis. This evidence concerns the gene NFE2L2 and Myocardial fibrosis.